Recently, a patient infected with A. baumannii that lacked susceptibility to all commercially available antimicrobial drugs has been reported.
The patient had a prolonged stay in an intensive care unit at the University of Pitts-burgh Medical Center (Pittsburgh, PA, USA). In the tenth postoperative week, ventilator-associated pneumonia developed, which was caused by A. baumanni that lacked susceptibility to all antimicrobial drugs tested except colistin. Despite multiple courses of therapy with colistin and cefepime, the patient never recovered from respiratory failure. She eventually died of sepsis caused by vancomycin-resistant E. faecium. An A. baumannii isolate, obtained just before she died, lacked susceptibility to all commercially available antimicrobial drugs.
Experimental and clinical isolates lacking susceptibility to colistin, often considered the drug of last resort, are increasingly being reported.
Therefore, we alert healthcare workers to the need for stringent care in adhering to infection control precautions when caring for patients infected with multidrug-resistant A. baumannii. Use of contact isolation precautions, enhanced environmental cleaning, removal of sources of infection from the hospital environment, and prudent use of antimicrobial drugs can contribute to control of such outbreaks. A crisis is looming should multidrug-resistant A. baumannii become established pathogens in hospitals.
The report was published in the journal Emerging Infectious Diseases.
Abstract of this article.